VYTORIN Treats the 2 sources of cholesterol
Possible Side Effects When Taking VYTORIN
See your doctor regularly to check your cholesterol level and to check for side effects. Your doctor should do blood tests to check your liver before you start taking VYTORIN and if you have any symptoms of liver problems while you take VYTORIN. Call your doctor right away if you have the following symptoms of liver problems:
  • Loss of appetite
  • Upper belly pain
  • Dark urine
  • Yellowing of your skin or the whites of your eyes
  • Feel tired or weak

In clinical studies, patients reported the following common side effects while taking VYTORIN:
  • Headache
  • Increased liver enzyme levels
  • Muscle pain
  • Upper respiratory infection
  • Diarrhea

The following side effects have been reported in general use with VYTORIN or with ezetimibe or simvastatin tablets (tablets that contain the active ingredients of VYTORIN):
  • Allergic reactions including swelling of the face, lips, tongue, and/or throat that may cause difficulty in breathing or swallowing (which may require treatment right away), rash, hives
  • Joint pain
  • Inflammation of the pancreas
  • Nausea
  • Dizziness
  • Tingling sensation
  • Depression
  • Gallstones
  • Trouble sleeping
  • Poor memory
  • Memory loss
  • Confusion
  • Erectile dysfunction
  • Breathing problems including persistent cough and/or shortness of breath or fever
Tell your doctor if you have any side effect that bothers you or does not go away.

These are not all the possible side effects of VYTORIN (ezetimibe and simvastatin). For more information, ask your doctor or pharmacist.

Call your doctor about medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

VYTORIN contains two cholesterol medicines, Zetia (ezetimibe) and Zocor (simvastatin), in a single tablet. VYTORIN has not been shown to reduce heart attacks or strokes more than Zocor alone.

Important Risk Information About VYTORIN
VYTORIN is a prescription tablet and isn’t right for everyone. This includes anyone taking certain medicines or foods that may increase your risk of serious muscle problems with VYTORIN. These medicines include certain antifungals and antibiotics, HIV protease inhibitors, certain hepatitis C virus protease inhibitors, nefazodone, medicines containing cobicistat, gemfibrozil, cyclosporine, and danazol. So, tell your doctors about any other medications you are taking. VYTORIN also isn’t right for people who are allergic to any of its ingredients, women who are nursing or pregnant or who may become pregnant, and anyone with liver problems.

Unexplained muscle pain or weakness could be a sign of a rare but serious side effect and should be reported to your doctor right away. This side effect can rarely cause kidney damage that can lead to death. Also notify your doctor if you have muscle problems that do not go away even after your doctor has advised you to stop taking VYTORIN. The risk of serious muscle problems is greater with higher doses of VYTORIN, particularly the highest dose (10/80 mg). The highest dose should only be used by people who have been taking it chronically (such as 12 months or more) without having muscle damage and who don’t need to take certain other medicines.

Your doctor should do simple blood tests to check for liver problems before treatment with VYTORIN and if you have symptoms of liver problems during treatment. Tell your doctor right away if you have loss of appetite, upper belly pain, dark urine, or yellowing of your skin or the whites of your eyes, or if you feel tired or weak. Side effects of VYTORIN included headache, increased liver enzyme levels, muscle pain, upper respiratory infection, and diarrhea.

For more information, see FAQs About VYTORIN.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. Please read the accompanying Patient Information for
VYTORIN (ezetimibe and simvastatin) and discuss it with your doctor. The physician Prescribing Information also is available.
This site is intended only for residents of the United States, its territories, and Puerto Rico.
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